Th17 cells and IL-17 promote the skin and lung inflammation and fibrosis process in a bleomycin-induced murine model of systemic sclerosis. - Concepedia

Concepedia

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Th17 cells and IL-17 promote the skin and lung inflammation and fibrosis process in a bleomycin-induced murine model of systemic sclerosis.

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2017

Year

Ling Lei, Cheng Zhao, Fang Qin, Zhiyi He, Xu Wang, Xiao-ning Zhong

Abstract

Our results indicate that Th17 cells participate in the pathogenesis of skin and lung fibrosis by enhancing fibroblast proliferation and cytokine production in a mouse BLM model of SSc.