Circulating Virus, Interferon and Antibody after Vaccination with the 17-D Strain of Yellow-Fever Virus

Abstract

CIRCULATING interferon has been induced in laboratory animals by the inoculation of several different viruses.1 , 2 In man circulating interferon has been detected after the intravenous administration of viruses to a patient with acute leukemia3 as well as in a number of patients with naturally occurring clinical viral infections.4 In the latter the lack of virus isolations precluded the establishment of any relation between the type of virus, time of infection and virus, interferon and antibody production. In an attempt to establish these relations recent studies both in this laboratory and elsewhere have been concerned with infections produced by live-virus vaccines, . . .