Induction of Graft-versus-Host Disease as Immunotherapy for Relapsed Chronic Myeloid Leukemia

Abstract

The induction of a graft-versus-leukemia reaction with interferon alfa-2b and infusions of donor mononuclear cells in patients with CML in relapse after bone marrow transplantation is an effective antileukemic therapy that may offer an alternative to a second marrow transplantation.