Deletion of GIRK2 Subunit of GIRK Channels Alters the 5-HT_1AReceptor-Mediated Signaling and Results in a Depression-Resistant Behavior

Abstract

Our results indicate that GIRK channels formed by GIRK2 subunits determine depression-related behaviors as well as basal and 5-HT1A receptor-mediated dorsal raphe neuronal activity, becoming alternative therapeutic targets for psychiatric diseases underlying dysfunctional serotonin transmission.