Immune Deficiencies, Aplastic Anemia and Abnormalities of Lymphoid Tissue in Thymoma

Abstract

THERE is a wealth of clinical information documenting the association of thymoma with a variety of disorders of the hematopoietic1 2 3 and lymphoid systems, immunoglobulin metabolism4 5 6 and neuromuscular transmission.7 , 8 Although recent studies have emphasized the crucial role of the thymus in the ontogeny of the lymphoid system, and in the genesis and modulation of the immune response,9 , 10 there is still no clear understanding of the relation between the pathologically altered thymus and the diverse clinical derangements that often accompany it.This report presents a case of thymoma and associated hematologic and immunologic disorders whose clinical and histologic features appear in several . . .