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Interferon-alpha associated arthritis.
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1997
Year
InflammationRheumatologyRheumatoid DisorderAutoimmune DiseaseViral HepatitisRheumatic DiseasesMedicineImmunologyOsteoarthritisHepatitisAutoimmunityPaediatric RheumatologyInflammatory Rheumatic DiseaseImmune-mediated Inflammatory DiseasesProgressive Inflammatory PolyarthritisPsoriatic ArthritisInflammatory ArthritisRheumatoid Arthritis
We describe a patient who developed progressive inflammatory polyarthritis after treatment with interferon-alpha (IFN-alpha) for chronic hepatitis C infection. Rechallenge with the drug caused worsening of the arthritis, but withdrawal did not result in remission. Preexisting autoantibodies and HLA-DR4 were detected in this serum and are thought to be relevant in the etiology of IFN-alpha associated autoimmune disease.