Ex vivo investigation of glycerol diffusion in skin tissue

Abstract

The change of optical parameters of rat skin ex vivo under the action of aqueous 30%, 50%, 60%, 70%, 85%, and 100% glycerol solutions has been experimentally studied. The analysis of kinetics of the change of the studied parameters has allowed the estimate of the diffusion coefficient dependence upon the concentration of glycerol in the skin and the efficiency of optical clearing for each of the glycerol solutions. The results can find application in the development of new methods of noninvasive diagnostics and therapy of skin diseases.