PubMed · 2012 · 103 citations · 0 references
MedicineMaxillofacial SurgeryOral SurgeryBone AugmentationBone GraftingTissue EngineeringBone Graft MaterialsBone Graft SubstitutesBone RegenerationBone SubstitutesOsteogenesisSynthetic Bone SubstitutesHealing Period DurationHealing ProcessesMaxillary Bone RegenerationNew Bone FormationSinus Graft MaterialsSynthetic Bone Graft MaterialsTissue Engineering Augmentation
Sinus augmentation with various bone graft materials may be required in the posterior maxilla. This study compared bone formation in a lateral window sinus augmentation with recombinant human bone morphogenetic protein 2/acellular collagen sponge (rhBMP-2/ACS) combined with Bio-Oss or Bio-Oss graft alone. Patients were assigned to treatment with either rhBMP-2/ACS + Bio-Oss or Bio-Oss alone. After a healing period, bone cores were harvested. Histologic specimens demonstrated that new bone formation was less in those who received rhBMP-2/ACS + Bio-Oss than those with Bio-Oss alone. This study indicated that the addition of rhBMP-2/ACS to Bio-Oss has a negative effect on bone formation.