Copper-Catalyzed sp³ C–H Aminative Cyclization of 2-Alkyl-<i>N</i>-arylbenzamides: An Approach for the Synthesis of <i>N</i>-Aryl-isoindolinones

Abstract

The synthesis of isoindolinones via copper-catalyzed sp(3) C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.