Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes

Abstract

We have demonstrated a facile synthesis of diversely substituted quinazolines and 3,4-dihydroquinazolines through the <i>o</i>-iodoxybenzoic acid (IBX) mediated tandem reaction of readily available <i>o</i>-aminobenzylamine and aldehydes. The yield of the reactions generally ranged from 70% to 95%. This mild protocol provides an efficient strategy toward the synthesis of these classes of heterocycles.