Delamanid susceptibility testing of<i>Mycobacterium tuberculosis</i>using the resazurin microtitre assay and the BACTEC™ MGIT™ 960 system

Abstract

We established protocols for DST of delamanid in the MGIT and REMA, confirming their feasibility in routine TB diagnostics, utilizing the same discriminative concentration for both methods. Moreover, taking advantage of WGS analysis, we identified polymorphisms potentially associated with resistance in two genes involved in delamanid activation.