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Metal-Free Amidation of Acids with Formamides and T3P®
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2016
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Combinatorial ChemistryDirect FormationEngineeringMetal-free MethodOrganic ChemistryMetal-free AmidationAmine SourceChemistrySynthetic ChemistryBiomolecular Engineering
A new, simple and metal-free method for the direct formation of dialkylamides from carboxylic acids employing <i>N</i>,<i>N</i>-dialkylformamides as amine source is described. The one-pot reaction is promoted by propylphosphonic anhydride (T3P<sup>®</sup>) in the presence of 0.5 equivalents of HCl.