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Homogeneously Staining Region in a Retinoblastom Cell Line: Relevance to Tumor Initiation and Progression<xref ref-type="fn" rid="FN2">2</xref><xref ref-type="fn" rid="FN3">3</xref>

DOI

35

Citations

0

References

1981

Year

Fred Gilbert, Gloria Balaban, W. Roy Breg, Brenda L. Gallle, Ted W. Reid, Warren W. Nichols
JNCI Journal of the National Cancer Institute

Abstract

A human retinoblastoma cell line was found to contain a homogeneously staining region (HSR) on chromosome 1 (at 1p34). An HSR had previously been identified at the same site in a human neuroblastoma cell line. Of the original retinoblastoma line, a subpopulation was found which did not contain the 1pHSR but did contain a 3p+ chromosome in which the additional segment resembled a small HSR. The 3p+ was most likely the result of the translocation between the 1pHSR and the short arm of a chromosome 3. Preliminary results also indicate that the retinoblastoma cells with the 1pHSR produced tumors in athymic nu/nu mice in an average of 28 days, while identical numbers of the retinoblastoma cells with the 3p+ (probable HSR) produced tumors in an average of 75 days.