Ameliorative Effect of Alkaloidal Fraction of Leaves of Alstonia scholaris Against Acetic Acid Induced Colitis via Modulation of Oxido-nitrosative and Pro-inflammatory Cytokines

Abstract

Background: Inflammatory Bowel Disease (IBD) is a chronic inflammatory, an idiopathic disorder of intestine with unknown etiology. Alstonia scholaris Linn., R.Br. (family Apocynaceae) shown to possesses potent antioxidant and anti-inflammatory activity. Objective: To evaluate the effect of an alkaloidal fraction of leaves of Alstonia scholaris (AFEAS) against acetic acid induced IBD in laboratory rats.