Formulation and evaluation of topical gel of diclofenac sodium using different polymers

Abstract

A wide choice of vehicles ranging from solids to semisolids form has been used for skin care and topical treatment of dermatological disease, High molecular weight water soluble polymers of Hydroxypropyl methylcellulose (HPMC), Carbapol 934P, Sodium alginate that possess very high viscosity, transparency, film forming properties at low concentration, are reported to useful in formation of gel. In the present investigation Diclofenac sodium gels were prepared for topical drug delivery by using different concentration of HPMC, Sodium alginate, Carbapol 934P, with an objective to increase transparency and spreadability. From the study it was concluded that HPMC gel containing Diclofenac sodium showed good consistency, homogeneity, spreadability and stability and has wider prospect for topical preparations as compared to Sodium alginate, Carbapol 934P gel containing Diclofenac sodium.