Small · 2016 · 25 citations · 50 references
EngineeringBiomedical EngineeringRadiologyBiomedical ImagingDiagnostic ImagingNanomaterialsCarbon NanotubesContrast AgentsMagnetic Resonance ImagingNanomedicineNanoparticle CharacterizationNanotubesIron Oxide NanoparticlesNanocarriersNanoparticle Contrast AgentsNanoparticle Imaging AgentsNanoparticle Imaging ProbesNanoparticle-based Contrast AgentsNanoparticle-based ProbesNanoparticle-mediated Imaging
Carbon nanotubes (CNTs) have been advocated as promising nanocarriers in the biomedical field. Their high surface area and needle-like shape make these systems especially attractive for diagnostic and therapeutic applications. Biocompatibility, cell internalization, biodistribution, and pharmacokinetic profile have all been reported to be length dependent. In this study, further insights are gotten on the role that the length of CNTs plays when developing novel contrast agents for magnetic resonance imaging (MRI). Two samples of CNTs with different length distribution have been decorated with radio-labeled iron oxide nanoparticles. Despite characterization of the prepared hybrids reveals a similar degree of loading and size of the nanoparticles for both samples, the use of short CNTs is found to enhance the MRI properties of the developed contrast agents both in vitro and in vivo compared to their long counterparts.
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Jie Liu, Andrew G. Rinzler, Hongjie Dai et al. · Science · 1998 · 2.9K citations
In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice
Weibo Cai, Nozomi Nakayama, Xiaoming Sun et al. · Nature Nanotechnology · 2006 · 1.4K citations