Selective Gamma-G Globulin Deficiencies in Patients with Recurrent Pyogenic Infections

Abstract

Three patients with lifelong susceptibility to pyogenic infections and progressive pulmonary disease were found to have selective deficiencies in their γG globulins. The serum of the first patient contained abnormally low concentrations of γG1, γG2 and γG4; the serum of the second patient was deficient in γG1, γG2 and γG3, and the third patient lacked γG1 and γG2. The serum concentrations of the other immunoglobulins were either normal or elevated. None of these abnormalities could be shown to have a genetic basis. Gamma-globulin replacement therapy prevented recurrence of infection in these patients.