Influence of Thiazide Diuretics on Carbohydrate Metabolism in Patients with Mild Diabetes

Abstract

THE usefulness of thiazide diuretics in clinical practice has been established. Particular interest in these compounds stems from several reports concerning their effect on carbohydrate metabolism. Wilkins1 and Freis2 both mentioned in 1959 that these agents caused hyperglycemia in several of their hypertensive patients. In the following year Goldner et al.3 studied the problem in a more systematic manner. Twenty nondiabetic subjects and 20 diabetic patients were given various diuretics by mouth. The nondiabetic group showed no elevation of blood sugar or change in glucose tolerance tests while receiving the thiazide, but 6 of the diabetic patients responded with an . . .