Synthesis, characterization and antitumor activity of novel tetrapodal 1,4-dihydropyridines: p53 induction, cell cycle arrest and low damage effect on normal cells induced by genotoxic factor H₂O₂

Abstract

Synthesis of novel tetrakis(2,6-dimethyl-4-phenyl-1,4-dihydropyridinyl)methanes<bold>5a–d</bold>by acid-catalyzed condensation of the tetrakis-aldehydes<bold>6a–d</bold>with eight equivalents of 3-aminobut-2-enenitrile<bold>2</bold>is reported. Antitumor activities of compounds<bold>5a–d</bold>were also investigated.