Hepatogastroenterology

Abstract

There is an inverse correlation between Snail and E-cadherin expression and a positive correlation between Snail and MMP-2 expression in HCC in vitro and in vivo. Snail downregulates E-cadherin and upregulates MMP-2 expression and promotes invasion in human HCC. Furthermore, Snail inhibition could both upregulate E-cadherin and downregulate MMP-2 expression and inhibit the invasion and metastases in human HCC.