Oral Glucose Tolerance in Negro Men Deficient in Glucose-6-Phosphate Dehydrogenase

Abstract

CHANMUGAM and Frumin1 have recently reported abnormal responses to oral glucose tolerance tests in adults with glucose-6-phosphate dehydrogenase (G6PD) deficiency.1 The abnormal responses included diabetic glucose tolerance curves or elevated two-hour serum glucose levels in 11 of 13 G6PD-deficient subjects, all but 1 of whom were Negroes. These responses are not in accord with the results of standard oral glucose tolerance tests conducted with G6PD-deficient Negro men at this laboratory during the past ten years. In this report we present the results of these tests and of additional studies carried out to compare the metabolism of glucose in G6PD-deficient and . . .