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Hydroxyurea Analogues of Fosmidomycin
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2003
Year
Bioorganic ChemistryEngineeringHydroxyurea AnaloguesAntibiotic AdjuvantAbstract BenzyloxyureasOrganic ChemistryAntimicrobial ChemotherapyChemistryPharmaceutical ChemistryMedicinal ChemistryDiversity Oriented SynthesisStereoselective SynthesisDiversity-oriented SynthesisPhosphonic Acids 6Phosphonic Esters 4PharmacologyBiomolecular EngineeringNatural SciencesSynthetic Chemistry
Abstract Benzyloxyureas (4) have been prepared by reactions of diethyl 3-benzyloxyamino-propyl-phosphonate (3) with isocyanates, potassium cyanate or 1,1’-carbonyldiimidazole / methylamine. Conversion of phosphonic esters 4 into phosphonic acids 6 by means of bromotrimethylsilane and catalytic hydrogenation of 4, 6 afforded the target compounds 5, 7.