Cyclophosphamide Therapy in Childhood Neuroblastoma

Abstract

THE role of chemotherapy in the management of the child with neuroblastoma remains to be defined. Until recently, conventional therapy has consisted of a combination of surgery and radiotherapy, whereas chemotherapy has usually been reserved for palliation of children with advanced metastatic disease. This approach can be attributed to the fact that no specific agent has been of consistent value in the treatment of this neoplasm. Since the introduction of cyclophosphamide to clinical investigation in this country in 1958 reports from various investigators1 2 3 have indicated a more consistent pattern of response with this drug, especially in advanced disease, than has . . .