Highly connected neurons spike less frequently in balanced networks

Abstract

Biological neuronal networks exhibit highly variable spiking activity. Balanced networks offer a parsimonious model of this variability in which strong excitatory synaptic inputs are canceled by strong inhibitory inputs on average, and irregular spiking activity is driven by fluctuating synaptic currents. Most previous studies of balanced networks assume a homogeneous or distance-dependent connectivity structure, but connectivity in biological cortical networks is more intricate. We use a heterogeneous mean-field theory of balanced networks to show that heterogeneous in-degrees can break balance. Moreover, heterogeneous architectures that achieve balance promote lower firing rates in neurons with larger in-degrees, consistent with some recent experimental observations.