A Possible Autoimmune Basis for Addison's Disease in Three Siblings, One with Idiopathic Hypoparathyroidism, Pernicious Anemia and Superficial Moniliasis

Abstract

FAMILIAL Addison's disease is an uncommon entity. In 1959 Meakin, Nelson and Thorn1 reviewed the literature and found 5 cases of familial Addison's disease documented by steroid studies or autopsy findings,2 3 4 5 6 and reported another case. Since that time 4 additional cases fulfilling their criteria have been reported.7 8 9 10 The association of superficial moniliasis, idiopathic hypoparathyroidism and Addison's disease is even rarer, only 6 cases being found in the literature.11 12 13 14 15 The purpose of this report is to describe a family in which Addison's disease was present in 3 siblings, 1 of whom also had superficial moniliasis, idiopathic hypoparathyroidism and pernicious anemia. We . . .