Dorsal Anterior Cingulate Lactate and Glutathione Levels in Euthymic Bipolar I Disorder:¹H-MRS Study

Abstract

This is the most extensive magnetic resonance spectroscopy study of lactate and glutathione in bipolar disorder to date, and results indicated that euthymic bipolar disorder patients had higher levels of lactate, which might be an indication of altered mitochondrial function. Moreover, lactate levels correlated with glutathione levels, indicating a compensatory mechanism regardless of bipolar disorder diagnosis.