Prophylaxis against Disseminated<i>Mycobacterium avium</i>Complex with Weekly Azithromycin, Daily Rifabutin, or Both

Abstract

For protection against disseminated M. avium complex infection, once-weekly azithromycin is more effective than daily rifabutin and infrequently selects for resistant isolates. Rifabutin plus azithromycin is even more effective but is not as well tolerated.