Pelger–Huët Anomaly of the Leukocytes

Abstract

IN 1928, Pelger,1 a Dutch physician and specialist in tuberculosis, examined the blood smear of a tuberculous patient and noted the absence of the usual nuclear segmentation in the granulocytic leukocytes. A large percentage of the cells were stab forms. The rest showed only two segments, and a few showed three segments but none more than three. In spite of this apparent immaturity, the nuclear chromatin was coarse, grouped into irregular clumps and obviously quite mature. In 1931, he had another case, again in a patient with tuberculosis, and thus the condition was first associated with this disease.2 Later in . . .