American Journal of Tropical Medicine and Hygiene · 2006 · 12 citations · 25 references
Veterinary MedicineImmunologyToxicologyAdaptive ImmunityImmunotoxicologyParasite ImmunologyAdaptive Immune ResponsesAdaptive Immune Responses To ParasitesAdaptive Immunity To ParasitesHost-parasite Immune InteractionsImmunoregulation In Parasitic InfectionProtozoan ImmunologyAdaptive Immunity To Protozoan ParasitesHost Immune Response ModulationHost Immune SuppressionImmune Suppression MechanismsImmunopathology Of LeishmaniasisLeishmaniasis PathogenesisLeishmaniasis PathologyLymphoid Organ Atrophy
Acute exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) can suppress adaptive immunity. In this study, pre-exposure of Leishmania major-infected mice to TCDD caused a dose-dependent and unexpected decrease in parasite burdens on day 20 after infection. In contrast, TCDD-mediated lymphoid atrophy, suppressed antibody levels, and enhanced interleukin-2 production were observed as expected. These results suggest that TCDD may enhance resistance to L. major in the face of immune suppression.
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Dong Yang, Neil F. Fairweather, Linda L. Button et al. · The Journal of Immunology · 1990 · 187 citations · Full text
Beth A. Vorderstrasse, Linda B. Steppan, Allen E. Silverstone et al. · Toxicology and Applied Pharmacology · 2001 · 164 citations