Structures of the Steroidal Alkaloids 25-Isosolafloridine and Solacallinidine Isolated From <i>Solanum callium</i>

Abstract

The two major alkaloids isolated from Solanum callium are 25-isosolafloridine and solacallinidine, which have the structures (25 S )-22,26-epimino-5a-cholest-22(N)-ene-3ß,16a -diol (la) and (25s)- 3~-amino-22,26-epimino-5a -cholest-22(N)-en-l6a -o1 (lla), respectively. The somewhat different properties reported by previous workers for a synthetic compound described as 25-isosolafloridine indicate that it was probably not stereoisomerically pure.