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Molecular and Biological Properties of Human Macrophage Growth Factor, CSF-1
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1986
Year
Human GrowthImmunologyImmune RegulationBiological PropertiesCell ProliferationCell GrowthInflammationStem Cell MobilizationAutophagyCell SignalingGranulocyteMature MacrophagesAutoimmunityHuman Csf-1Cell BiologyTumor MicroenvironmentMyelopoiesisPhagocyteCytokineImmune Cell DevelopmentCsf-1 BelongsMedicine
CSF-1 belongs to a family of colony-stimulating factors (CSF) that regulate the production of the blood cells (Metcalf 1984). CSF-1 is a specific growth and differentiation factor for bone-marrow progenitor cells of the mononuclear phagocyte lineage and also promotes the proliferation of mature macrophages via specific receptors on the responding cells (Das et al. 1981; Das and Stanley 1982). CSF-1 also has a variety of stimulatory effects on the function of macrophages and monocytes. In this paper, we summarize the cloning of the cDNA and the genomic structure of human CSF-1, and we describe properties of the macrophage growth factor that may make it a useful drug in several clinical settings.