Influence of Thyroactive Compounds on Serum and Liver Cholesterol in Rats.

Abstract

In a series of 5 separate experiments, rats were fed high fat and high fat-high cholesterol diets and were treated with various thyroactive compounds. Two dosages of 3;5,3′-triiodothyropropionic acid (Triprop) (0.03 mg and 0.15 mg/100 g body weight) were administered subcutaneously and, in general, were found to lower serum and liver cholesterol levels when compared with controls. Administration of D-thyroxine (0.05 mg/100 g body weight) and L-thyroxine (0.005 mg/100 g) also lowered serum and liver cholesterol levels. Among individual experiments there was a variation in magnitude, and in a few instances in the direction. of effect.