Preferential Retention of Taurine-Conjugated Bile Salts by Cholestyramine in the Rat Ileum

Abstract

In the absence of cholestyramine both glycine- and taurine-conjugated bile salts were rapidly absorbed from the rat ileum. Equilibration of bile salts with the resin prior to ileal instillation retarded, but did not completely interrupt, bile salt absorption. Cholestyramine retained the taurine conjugates of both the dihydroxy and the trihydroxy bile salts in the ileum more effectively than the corresponding glycine conjugates, and preferentially retained dihydroxy bile salts compared with trihydroxy bile salts.