Pharmacokinetics of nateglinide and its metabolites in subjects with type 2 diabetes mellitus and renal failure

Abstract

Single 90 mg dose of nateglinide was safe and effective in patients with renal failure. However, repeated administrations could cause prolonged hypoglycemia due to accumulation of M1, which is known to have a modest hypoglycemic activity. Hemodialysis may help to eliminate excessive accumulation of M1.