Sevoflurane preconditioning improves mitochondrial function and long-term neurologic sequelae after transient cerebral ischemia

Abstract

Sevoflurane preconditioning protects mitochondria from cerebral ischemia/reperfusion injury and ameliorates long-term neurological deficits. Inhibition of mitochondrial permeability transition pore opening is a crucial step in mediating the neuroprotection of sevoflurane preconditioning.