Synthesis of new cephalosporins with potent antibacterial activities.

Abstract

Cephalosporins bearing (Z)-and (E)-2-hydroxyimino-2-(2-imino-4-thiazolin-4-yl)-acetamido groups at the 7-position (5 and 6) were synthesized. Among them (Z)-isomers (5) showed superior activities particularly against Gram-negative bacteria to hitherto known cephalosporins.