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Changes in Plasma Prothrombin, Ac-Globulin, and Antithrombin Concentration Following Intravenous Administration of Estrogens.
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1957
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Prothrombin ConcentrationGynecologyReproductive EndocrinologyThrombosisHematologyPlasma ProthrombinAntithrombin ActivitySteroid MetabolismHealth SciencesAnimal PhysiologyEndocrine MechanismPlasma AcglobulinEndocrinologyPharmacologyOvarian HormonePhysiologyVeterinary ScienceMedicineEndocrine ResearchReproductive HormoneAnesthesiology
Solutions of estrogenic steroids were administered intravenously to dogs. There was a sharp rise in the plasma Acglobulin and prothrombin concentration. These changes began within the first 15 minutes, reached a peak in about 1 and 1/2 hours. In about 3 or 4 hours normal concentrations were again found. A small decrease in antithrombin activity of plasma was found. Theoretically all these changes tend to enhance coagulability of the blood.