Copper-Catalyzed Aerobic C(sp²)–H Functionalization for C–N Bond Formation: Synthesis of Pyrazoles and Indazoles

Abstract

A simple, practical, and highly efficient synthesis of pyrazoles and indazoles via copper-catalyzed direct aerobic oxidative C(sp(2))-H amination has been reported herein. This process tolerated a variety of functional groups under mild conditions. Further diversification of pyrazoles was also investigated, which provided its potential for drug discovery.