Studies on Chemotherapeutic Agents.I. A Synthesis of Pyrimidine Nucleosides of D-glucuronic Acid and Its Derivatives

Abstract

_D-Glucuronic acid nucleotides of uracil (VI, VIII), thymine (XVIII), cytosine (VII), 5-bromo-and 5-iodo-uracil (IX, X) were prepared by Hilbert-Johnson and Fox's procedures for the syntheses of pyrimidine nucleosides. VI was also obtained from 1-deoxy-1-(2, 4-dioxo-1, 2, 3, 4-tetrahydro-1-pyrimidinyl)-β-D-glucopyranose by O2-oxidation in the presence of Pt-catalyst. The structure and properties of the nucleosides synthesized were bridefly discussed.