Concepedia

Thalidomide for steroid-dependent immune reconstitution inflammatory syndromes during AIDS

Anne‐Sophie Brunel, Jacques Reynes, Édouard Tuaillon, Pierre‐Alain Rubbo, Olivier Lortholary, Brigitte Montès, Vincent Le Moing, Alain Makinson

AIDS · 2012 · 70 citations · 11 references

DOI

Concepts

Abstract

Management of relapsing or refractory immune reconstitution inflammatory syndromes (IRISs) despite corticosteroid therapy is yet to be defined. We describe three HIV-infected patients with corticosteroid-dependent and life-threatening paradoxical immune reconstitution inflammatory syndrome for whom thalidomide treatment induced rapid clinical remission and permitted complete corticosteroid withdrawal without clinical relapse.

References

11

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Thalidomide for the Treatment of Oral Aphthous Ulcers in Patients with Human Immunodeficiency Virus Infection

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Randomized placebo-controlled trial of prednisone for paradoxical tuberculosis-associated immune reconstitution inflammatory syndrome

Graeme Meintjes, Robert J. Wilkinson, Chelsea Morroni et al. · AIDS · 2010 · 405 citations

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Lewis Haddow, Robert Colebunders, Graeme Meintjes et al. · The Lancet Infectious Diseases · 2010 · 296 citations · Full text

, , +16