Effect of Cortisone on Histamine Liberation Induced by Tween in the Dog.

Abstract

(1) The injection of Tween 20 in the dog is followed by the appearance of histamine in the plasma, as demonstrated by paper chromatography. (2) Cortisone does not prevent the hypotensive effect of the first injection of Tween 20, in the male dog. (3) Cortisone prevents or decreases the hypotensive effect of a second injection of Tween 20 administered 24 or 48 hours after the first injection. (4) Cortisone does not prevent the hypotensive effect of injected histamine. (5) It is postulated that cortisone prevents the accumulation of histamine in the tissues following the release of this compound by Tween 20.