Concepedia

Antitumor activity among derivatives of the 3-chloro-4-(3-hydroxyanilino) -2,5-dihydropyrrole-2,5-dione

S. S. Tarnavsky, Sergey Golovach, S. M. Yarmoluk

Biopolymers and Cell · 2003 · 14 citations · 2 references

Open access

Concepts

PharmacyMedicinal ChemistryPharmacologyCancer PharmacologyStructure-activity RelationshipsSynthetic Medicinal ChemistryEnzyme InhibitionStructure-activity Relationship AnalysisAnticancer ActivityAnticancer Mechanism Of ActionChemical Structure-activity RelationshipsMedicinal Heterocycles

Abstract

Gho < 0,5 10~7 < 10~8 .

References

2

Inhibitors of Cyclin-Dependent Kinases as Anti-Cancer Therapeutics

Peter M. Fischer, David P. Lane · Current Medicinal Chemistry · 2000 · 147 citations

Medicine, Oncology, Pharmacology +16

Substitution at the F-Ring <i>N</i>-Imide of the Indolocarbazole Antitumor Drug NB-506 Increases the Cytotoxicity, DNA Binding, and Topoisomerase I Inhibition Activities

Christian Bailly, Xiaogang Qu, Jonathan B. Chaires et al. · Journal of Medicinal Chemistry · 1999 · 38 citations

Medicine, Medicinal Chemistry, Pharmacology +14