Intraventricular Angiotensin Elicits Drinking in the Baboon

Abstract

Cannulas aimed at the lateral cerebral ventricles were surgically implanted in baboons. A-II (5 /xg/animal) or control injections were made on subsequent days and water intake recorded to determine the patency of the cannulas. We found that (a) baboons drink considerable water after the IVT administration of A-II, (b) the response diminishes but still persists with repeated A-II tests spread over a several-month interval, and (c) elevated drinking in response to the administration of A-II is a practical way to confirm the success of ventricular cannulation.