Simultaneous Determination of Lower Alcohols, Acetone and Acetaldehyde in Blood by Gas Chromatography

Abstract

A gas chromatographic procedure is described for the simultaneous, quantitative, microdetermination of ethanol, methanol, isopropanol, acetaldehyde and acetone. By utilizing a column containing the polymer, Porapak Q, and interchangeable glass inlets, complete separation of these volatiles is achieved and whole blood may be directly injected without prior processing. This provides a simple, rapid, precise method for the determination of these toxic substances in the clinical and research laboratory.