Effect of Erythropoietin on the Uptake and Utilization of Iron by Bone Marrow Cells in vitro

Abstract

Purified sheep erythropoietin was found to enhance iron uptake and heme synthesis when added to a suspension of rabbit bone marrow. The greatest difference between control suspensions and erythropoietintreated suspension was found after 45 hours incubation in suspensions with a low cell count, with a medium enriched with tissue culture fluid and with an atmospheric oxygen tension of 13% oxygen.