Metabolism of Chlorpromazine. IV. Identification of 7-Hydroxychlor-promazine and Its Sulfoxide and Desmethyl Derivatives.

Abstract

A family of 4 phenolic metabolites of chlorpromazine has been isolated from animal (dog) and human urine by solvent extraction and paper chromatography. By subjecting the metabolites to a series of methylation and oxidation or reduction reactions, then comparing the products obtained to authentic material, they have been identified as follows: 7-hydroxychlorpromazine, 7-hydroxychlorpromazine sulfoxide, 7-hydroxy-nor1chlorpromazine, and 7-hydroxy-nor2chlorpromazine. These compounds are excreted both in free form and as glucuronic acid conjugates.