Mode of Action of Phenaglycodol, A New Neurosedative Agent

Abstract

Summary1. Phenaglycodol, a compound originally selected for clinical trial on the basis of its anticonvulsant and effective tranquilizing actions, has been shown to have a quieting effect on mice, cats and monkeys. 2. Its effects on blood pressure, respiration and electrocardiogram are minimal. 3. In studies on selected reflex arcs it has been shown to be a selective depressant of polysynaptic pathways at the spinal and supra-spinal level. 4. After doses of phenaglycodol causing sedation but not sleep in cats, the electroencephalogram shows a pattern of 9-12 c/sec. synchronous activity at both surface and deep electrodes.