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Mechanism of Sulfonamide Action. I. Acidic Dissociation and Antibacterial Effect
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1942
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EngineeringOrganic ChemistryAntimicrobial ChemotherapyChemistryDesulfurizationChemical BiologyIon ProcessSolution (Chemistry)Chemical EngineeringAnalytical ChemistryAnionic SpeciesAnion SensingActive AgentAntimicrobial ResistanceBiochemistryAntibacterial AgentAntimicrobial CompoundHydrogenPharmacologySulfonamide SolutionAcidic DissociationNatural SciencesMicrobiologyChemical Kinetics
From the nature of the function relating the effectiveness of sulfonamides to the hydrogen ion concentration the conclusion can be drawn that the active agent in a sulfonamide solution is an anionic species.