Comparison of Effect of Progesterone and 11-Ketoprogesterone upon Glycosuria of Partially Depancreatized Rat

Abstract

Partially depancreatized force-fed rats were injected with 1 to 100 mg per day of progesterone and 1 to 32 mg per day of 11-ketoprogesterone. Very large doses of progesterone caused exacerbation of the diabetes and 11-ketoprogesterone was found to be significantly more potent in this respect. The diabetogenicity of 11-ketoprogesterone is manifest in either the presence or absence of the adrenal glands.