Conservation of Binding Epitopes for Monoclonal Antibodies on the Rabies Virus Glycoprotein

Abstract

This study aims to determine the effect of Kaletra on functional and metabolic health in older mice with pre-existing over-weighted. Selected experiments were conducted in young mice for comparison. This research complied with the NIH guidelines on laboratory animal care and Institutional Animal Care and Use Committees (IACUC) of Boston University approved the protocol. Mice of two age groups were used. The older ones were at 20 month and over-weighted (~30% body fat mass at baseline) and the younger ones were at 6 month (15% body fat). Both were given a high fat food of 30% fat calorie. Detailed methods on diet, drug administration, and serum drug measurement, functional and molecular measurements are presented in the supplemental information section.